Serum syndecan-1 correlates with coronary artery calcification severity and intradialytic hypotension in elderly hemodialysis patients - Takeaways - MDSpire

Serum syndecan-1 correlates with coronary artery calcification severity and intradialytic hypotension in elderly hemodialysis patients

  • By

  • Dian Zhu

  • Yiyuan Zhang

  • Yu Song

  • Yu Xi

  • Mingzhe Zhu

  • Hailun Li

  • Donghui Zheng

  • Xue Zhao

  • June 11, 2026

  • 0 min

Share

  • 1

    Elevated serum syndecan-1 (SDC1) levels are significantly higher in elderly maintenance hemodialysis patients compared to healthy controls.

  • 2

    Serum SDC1 levels strongly correlate with coronary artery calcification severity, indicating potential vascular dysfunction.

  • 3

    After adjusting for various factors, higher SDC1 levels are independently associated with increased coronary artery calcification severity.

  • 4

    An SDC1 threshold of 33.5 pg/mL identifies patients with a higher prevalence of coronary artery calcification and more frequent intradialytic hypotension episodes.

  • 5

    The findings suggest that SDC1 may serve as a potential biomarker for vascular and hemodynamic instability in elderly hemodialysis patients.

Original Source(s)

Serum syndecan-1 correlates with coronary artery calcification severity and intradialytic hypotension in elderly hemodialysis patients

  • by Dian Zhu, Yiyuan Zhang, Yu Song, Yu Xi, Mingzhe Zhu, Hailun Li, Donghui Zheng, Xue Zhao

  • June 11, 2026

Related Content

Clinical analysis of drug treatment trends for coronary heart disease in China

When Bad Data Enters the Drug Pipeline

Federal prosecutors allege that a Florida physician and research staff fabricated clinical trial records that were submitted into database systems used to evaluate investigational drugs.

Comorbidity sequence, sex, and APOE-genotype forecast Alzheimer's disease diagnosis