Positron emission tomography-computed tomography in the diagnostic evaluation of smoldering multiple myeloma: identification of patients needing therapy - Takeaways - MDSpire

Positron emission tomography-computed tomography in the diagnostic evaluation of smoldering multiple myeloma: identification of patients needing therapy

  • By

  • B Siontis

  • S Kumar

  • A Dispenzieri

  • M T Drake

  • M Q Lacy

  • F Buadi

  • D Dingli

  • P Kapoor

  • W Gonsalves

  • M A Gertz

  • S V Rajkumar

  • October 23, 2015

  • 0 min

Share

  • 1

    Smoldering multiple myeloma (SMM) has a ~50% risk of progression to active malignancy within 5 years of diagnosis.

  • 2

    PET-CT imaging can identify high-risk SMM patients who may benefit from early treatment rather than observation.

  • 3

    In this study, 75% of patients with a positive PET-CT progressed to active multiple myeloma within 2 years.

  • 4

    Patients with positive PET-CT and underlying osteolysis had a median time to progression of 21 months.

  • 5

    The 5-year survival rate was 61% for patients with positive PET-CT compared to 82% for those with negative PET-CT.

Original Source(s)

Positron emission tomography-computed tomography in the diagnostic evaluation of smoldering multiple myeloma: identification of patients needing therapy

  • by B Siontis, S Kumar, A Dispenzieri, M T Drake, M Q Lacy, F Buadi, D Dingli, P Kapoor, W Gonsalves, M A Gertz, S V Rajkumar

  • October 23, 2015

Related Content

AstraZeneca Deepens China Cell Therapy Push

New Shanghai manufacturing base and innovation center will support CAR-T production and a broader UK-China life sciences collaboration

  • March 31, 2026

  • 2 min
Why are long-lived plasma cells long-lived?

Editorial: A new perspective on the importance of dendritic cells in cancer immunity: from bench to patient’s bedside