Chemogenetic activation of cholinergic intrinsic cardiac ganglia improves border zone oxygenation and reduces arrhythmias during acute local ischemia - Takeaways - MDSpire
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Stimulation of Cholinergic Neurons in Intrinsic Cardiac Ganglia Enhances Oxygenation in Border Zones and Mitigates Arrhythmias During Acute Local Ischemia

  • By

  • Bridget R. Alber

  • Aman Gill

  • Jhansi Dyavanpalli

  • David Mendelowitz

  • Matthew W. Kay

  • June 9, 2026

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  • 1

    Selective activation of cholinergic neurons in the intrinsic cardiac ganglia can reduce arrhythmias during acute myocardial ischemia.

  • 2

    Cholinergic ICG activation significantly improved oxygenation in ischemic border zone tissue after coronary occlusion.

  • 3

    DREADDs-mediated cholinergic ICG activation prolonged the PR interval and decreased arrhythmia incidence in transgenic rats.

  • 4

    The effects of cholinergic ICG activation were blocked by the muscarinic antagonist atropine, indicating a muscarinic-dependent mechanism.

  • 5

    Targeting the intrinsic cardiac cholinergic network may provide a novel therapeutic strategy for early intervention in myocardial infarction.

Original Source(s)

Chemogenetic activation of cholinergic intrinsic cardiac ganglia improves border zone oxygenation and reduces arrhythmias during acute local ischemia

  • by Bridget R. Alber, Aman Gill, Jhansi Dyavanpalli, David Mendelowitz, Matthew W. Kay

  • June 9, 2026

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