Association between peripheral blood T cell subsets and clinical disability in multiple sclerosis patients - Takeaways - MDSpire

Correlation of Peripheral Blood T Cell Subtypes with Clinical Disability Levels in Patients with Multiple Sclerosis

  • By

  • Penju Liu

  • Wei Liu

  • Xiaoting Zhang

  • Peng Yuan

  • July 20, 2026

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  • 1

    The study investigated the correlation between peripheral blood T cell subsets and clinical disability in multiple sclerosis patients.

  • 2

    Forty-eight MS patients were analyzed, revealing a mean EDSS score of 3.20 and a mean CD4+/CD8+ ratio of 2.76.

  • 3

    A negative correlation was found between the CD4+/CD8+ ratio and EDSS scores, indicating lower ratios associated with higher disability.

  • 4

    Stratified analysis showed a progressive decline in CD4+/CD8+ ratios across disability severity groups.

  • 5

    The association between CD4+/CD8+ ratio and EDSS was influenced by disease-modifying therapy exposure.

Original Source(s)

Association between peripheral blood T cell subsets and clinical disability in multiple sclerosis patients

  • by Penju Liu, Wei Liu, Xiaoting Zhang, Peng Yuan

  • July 20, 2026

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