Role of platelet-rich plasma in unexplained recurrent implantation failure: an umbrella review - Takeaways - MDSpire

Role of platelet-rich plasma in unexplained recurrent implantation failure: an umbrella review

  • By

  • Harpreet Kaur

  • Anil Chauhan

  • Muhammed Shabil

  • Mishu Mangla

  • July 8, 2026

  • 0 min

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  • 1

    The study evaluates the role of platelet-rich plasma (PRP) in women with unexplained recurrent implantation failure (RIF).

  • 2

    Fifteen systematic reviews of randomized controlled trials were included, revealing a high overlap in findings (42%).

  • 3

    The review indicated improvements in implantation, clinical pregnancy, and live birth rates, but the certainty of evidence was low or not reported.

  • 4

    Only five of the fifteen studies performed GRADE analysis, limiting the ability to make definitive recommendations.

  • 5

    Intrauterine infusion of PRP shows potential as an adjunct therapy for RIF, but the overall quality of evidence remains low.

Original Source(s)

Role of platelet-rich plasma in unexplained recurrent implantation failure: an umbrella review

  • by Harpreet Kaur, Anil Chauhan, Muhammed Shabil, Mishu Mangla

  • July 8, 2026

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