Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis - Takeaways - MDSpire

Comprehensive Immunophenotyping Identifies Unique Immune Profiles in Axial Spondyloarthritis and Psoriatic Arthritis

  • By

  • Natalie Frede

  • Nils Craig-Müller

  • Silke Kohrt

  • Marei-Theresa Bott

  • Ulrich Salzer

  • Ana Cecilia Venhoff

  • Jens Thiel

  • Julia Frede

  • Reinhard E. Voll

  • Marta Rizzi

  • Raquel Lorenzetti

  • Nils Venhoff

  • July 6, 2026

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  • 1

    Axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are distinct conditions within the spondyloarthritis spectrum.

  • 2

    The study compared immune cell subsets, cytokine profiles, and inflammatory mediators in axSpA and PsA patients.

  • 3

    Peripheral blood mononuclear cells from 179 patients and 49 healthy donors were analyzed using spectral flow cytometry.

  • 4

    AxSpA was characterized by an expansion of double-negative and γδ T cells, and increased plasmablasts and CD21low B cells.

  • 5

    Distinct immunophenotypic profiles were identified for axSpA and PsA, influencing disease course and therapeutic response.

Original Source(s)

Deep Immunophenotyping Reveals Distinct Immune Signatures in Axial Spondyloarthritis and Psoriatic Arthritis

  • by Natalie Frede, Nils Craig-Müller, Silke Kohrt, Marei-Theresa Bott, Ulrich Salzer, Ana Cecilia Venhoff, Jens Thiel, Julia Frede, Reinhard E. Voll, Marta Rizzi, Raquel Lorenzetti, Nils Venhoff

  • July 6, 2026

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