Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis - Takeaways - MDSpire

Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis

  • By

  • Yan Du

  • Lulu Zhang

  • Yiheng Cheng

  • Sijie Lu

  • Ronghua Ou

  • Xiaojian Deng

  • May 12, 2026

  • 0 min

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  • 1

    Neutrophil extracellular traps (NETs) and pyroptosis connect systemic autoimmune diseases to atherosclerosis through a self-amplifying inflammatory loop.

  • 2

    Gasdermin D amplifies NET release context-dependently, while Gasdermin E mediates critical interactions leading to structural damage in autoimmune conditions.

  • 3

    NETs serve as reservoirs of autoantigens in systemic lupus erythematosus and rheumatoid arthritis, exacerbating autoimmune responses and cardiovascular complications.

  • 4

    Emerging therapies targeting peptidylarginine deiminase 4 and gasdermin pore formation show promise in reducing systemic inflammation and cardiovascular risks.

  • 5

    Understanding the interplay between NETosis and pyroptosis is essential for developing targeted interventions to improve outcomes in chronic inflammatory disorders.

Original Source(s)

Neutrophil extracellular traps and pyroptosis: a molecular nexus linking systemic autoimmune diseases to atherosclerosis

  • by Yan Du, Lulu Zhang, Yiheng Cheng, Sijie Lu, Ronghua Ou, Xiaojian Deng

  • May 12, 2026

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