Recurrent Mixed Cryoglobulinemic Vasculitis After Influenza Immunization
-
October 6, 2026
-
1
An 83-year-old man developed bilateral lower-extremity purpura and acute kidney injury after influenza vaccination on 2 separate occasions, 1 year apart.
-
2
Skin biopsy showed leukocytoclastic vasculitis, and cryoprecipitate immunofixation demonstrated monoclonal IgM and polyclonal IgG, confirming type II cryoglobulinemic vasculitis.
-
3
Workup for viral, autoimmune, lymphoproliferative, and malignant causes did not identify an alternative etiology for either episode.
-
4
The second episode included transient PR3-ANCA positivity and more severe acute kidney injury; prednisone treatment was followed by gradual clinical improvement.
-
5
Renal biopsy showed acute tubular injury and diabetic glomerulosclerosis without immune complex–mediated disease or ANCA-associated crescentic glomerulonephritis; kidney function remained below baseli
Based on findings from:
Recurrent Mixed Cryoglobulinemic Vasculitis Following Influenza Vaccination
Annals Of Internal Medicine: Clinical Cases, 2026.
https://www.acpjournals.org/doi/10.7326/aimcc.2026.0399
This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.
