Research progress on the intervention of osteoporosis by Chinese herbal monomers based on the Nrf2/NF-κB/MAPK pathway - Takeaways - MDSpire
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Advancements in Osteoporosis Treatment Using Chinese Herbal Monomers Targeting the Nrf2/NF-κB/MAPK Signaling Pathway

  • By

  • Wenjie Kou

  • Chenglong Guo

  • Xiaomin Lu

  • Zhe Zhang

  • Kaiwen Liu

  • Zhihuan Liu

  • Bin Jiang

  • Chengxiang Ma

  • Jishu Li

  • Jiandong Gao

  • Linzhong Cao

  • Xiaogang Zhang

  • June 24, 2026

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  • 1

    Osteoporosis is a chronic metabolic bone disorder characterized by reduced bone mass and increased skeletal fragility.

  • 2

    The Nrf2, NF-κB, and MAPK pathways are crucial for regulating bone metabolism, oxidative stress, and inflammation.

  • 3

    Traditional Chinese medicine offers a multi-target approach to osteoporosis treatment, emphasizing individualized patient care.

  • 4

    Current osteoporosis treatments primarily rely on Western medications, which may have adverse effects and limitations.

  • 5

    Chinese herbal monomers can modulate key signaling pathways, potentially restoring bone metabolic equilibrium.

Original Source(s)

Research progress on the intervention of osteoporosis by Chinese herbal monomers based on the Nrf2/NF-κB/MAPK pathway

  • by Wenjie Kou, Chenglong Guo, Xiaomin Lu, Zhe Zhang, Kaiwen Liu, Zhihuan Liu, Bin Jiang, Chengxiang Ma, Jishu Li, Jiandong Gao, Linzhong Cao, Xiaogang Zhang

  • June 24, 2026

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