Plasma PZP level elevation: a potential correlate of diabetic kidney disease progression

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Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and end-stage renal disease in type 2 diabetes mellitus patients.
2

Plasma pregnancy zone protein (PZP) levels were significantly increased in DKD patients compared to controls in a validation cohort of 283 participants.
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Positive correlations were found between plasma PZP concentrations and clinical parameters such as systolic blood pressure, HbA1c, and urine albumin-to-creatinine ratio.
4

A multiple logistic regression analysis indicated a significant correlation between elevated PZP levels and DKD progression.
5

The study suggests that detecting plasma PZP concentrations may provide a basis for timely intervention in diabetic kidney disease.

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