The association of seizure control with neuropathology in dementia

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Active seizures in people with dementia are linked to faster cognitive decline and higher mortality rates compared to those with remote or no seizures.
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Participants with active seizures had a younger age at death and more severe dementia symptoms than those with remote seizures or controls.
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Post-mortem analyses revealed that active seizure participants exhibited more advanced Alzheimer's disease pathology than remote seizure participants and controls.
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Active seizures were associated with greater neurodegeneration, including cerebral and hippocampal atrophy, compared to controls.
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Clinicians should prioritize the detection of ongoing seizures in dementia patients, as they may indicate a worse prognosis.

Brain

by Ifrah Zawar, Aleksander Luniewski, Rithvik Gundlapalli, Carol Manning, Prachi Parikh, Jaideep Kapur, Mark Quigg
January 16, 2025

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