Development and validation of an m6A and autophagy related lncRNAs signature for predicting survival and modulating the immune microenvironment in esophageal squamous cell carcinoma

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A prognostic framework based on m6A- and autophagy-related lncRNAs was developed to predict survival in esophageal squamous cell carcinoma (ESCC).
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The study identified five key lncRNAs that significantly predict overall survival in ESCC patients through rigorous statistical analyses.
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Immune profiling revealed a unique immune phenotype associated with the prognostic model, highlighting specific immune cell infiltrations.
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Pharmacogenomic analysis identified nine compounds with differential sensitivity across risk strata, suggesting tailored therapeutic options.
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The findings provide insights into the m6A-autophagy-lncRNA regulatory axis, offering potential for improved prognostic assessment and targeted therapies.

Frontiers In Immunology

by Mingyi Yang, Honghao Ren, Jing Hu, Pengfei Wen, Jiale Xie, Xianjie Wan, Lin Liu, Zhi Yang, Ming Zhang, Xiaodong Ren, Yani Su
May 28, 2026

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