Programmed cell death ligand 1 in correlation with BRAFV600E mutation, molecular characteristics and biological behavior in ameloblastoma - Takeaways - MDSpire

Programmed cell death ligand 1 in correlation with BRAFV600E mutation, molecular characteristics and biological behavior in ameloblastoma

  • By

  • Aijing Pan

  • Zhipeng Xie

  • Jianhui Zhan

  • Yifeng Zhao

  • Yue Du

  • Kai Zhang

  • June 16, 2026

  • 0 min

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  • 1

    The study investigates PD-L1 expression in ameloblastoma and its correlation with the BRAFV600E mutation and immune cell markers.

  • 2

    Of 50 patients, 84% were PD-L1 positive, with a significant association between PD-L1 positivity and BRAFV600E mutation.

  • 3

    No significant correlations were found between PD-L1 and CD8+ T cells, FoxP3+ cells, or pathological subtype.

  • 4

    High CD8+ T cell infiltration was associated with prolonged disease-free survival in patients with ameloblastoma.

  • 5

    The findings suggest PD-L1 expression may influence the biological behavior of ameloblastoma, warranting further research.

Original Source(s)

Programmed cell death ligand 1 in correlation with BRAFV600E mutation, molecular characteristics and biological behavior in ameloblastoma

  • by Aijing Pan, Zhipeng Xie, Jianhui Zhan, Yifeng Zhao, Yue Du, Kai Zhang

  • June 16, 2026

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