Red Blood Cell Transfusion Characteristics and Morbidity or Mortality in Very-Low-Birth-Weight Infants - Takeaways - MDSpire

Red Blood Cell Transfusion Characteristics and Morbidity or Mortality in Very-Low-Birth-Weight Infants

  • By

  • Jeanne E. Hendrickson

  • Rebecca J. Birch

  • Elizabeth A. K. Rowley

  • Martha Sola-Visner

  • Brian R. Branchford

  • Xuxin Chen

  • Brian Custer

  • Robert A. DeSimone

  • Daniel W. Bougie

  • Erika M. Edwards

  • Ruchika Goel

  • Jerome Gottschall

  • Eldad A. Hod

  • Morvarid Moayeri

  • Nareg H. Roubinian

  • Oliver Karam

  • Jeffrey J. VanWormer

  • Elizabeth F. Stone

  • Naomi L. C. Luban

  • Cassandra D. Josephson

  • Ravi M. Patel

  • NHLBI Recipient Epidemiology Donor Evaluation Study–IV–Pediatric (REDS-IV-P)

  • Alan E. Mast

  • Lisa Baumann Kreuziger

  • Elliott P. Vichinsky

  • Bryan R. Spencer

  • Bruce S. Sachais

  • Kathy Chapman

  • Philip J. Norris

  • Mars Stone

  • Paul M. Ness

  • Steve H. Kleinman

  • June 24, 2026

  • 0 min

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  • 1

    More than half of very-low-birth-weight infants receive red blood cell transfusions, which can lead to complications like necrotizing enterocolitis and bronchopulmonary dysplasia.

  • 2

    A systematic review indicated no significant difference in outcomes between higher and lower red blood cell transfusion thresholds at discharge or neurodevelopmental follow-up.

  • 3

    The TIPI study aimed to identify transfusion characteristics linked to morbidity and mortality in VLBW infants using a comprehensive linked database.

  • 4

    The primary outcome of the study included severe complications such as grade 3 intraventricular hemorrhage, necrotizing enterocolitis, and death.

  • 5

    Statistical analyses were conducted using generalized estimating equations and Cox proportional hazard modeling to assess the impact of transfusion characteristics.

Original Source(s)

Red Blood Cell Transfusion Characteristics and Morbidity or Mortality in Very-Low-Birth-Weight Infants

  • by Jeanne E. Hendrickson, Rebecca J. Birch, Elizabeth A. K. Rowley, Martha Sola-Visner, Brian R. Branchford, Xuxin Chen, Brian Custer, Robert A. DeSimone, Daniel W. Bougie, Erika M. Edwards, Ruchika Goel, Jerome Gottschall, Eldad A. Hod, Morvarid Moayeri, Nareg H. Roubinian, Oliver Karam, Jeffrey J. VanWormer, Elizabeth F. Stone, Naomi L. C. Luban, Cassandra D. Josephson, Ravi M. Patel, NHLBI Recipient Epidemiology Donor Evaluation Study–IV–Pediatric (REDS-IV-P), Alan E. Mast, Lisa Baumann Kreuziger, Elliott P. Vichinsky, Bryan R. Spencer, Bruce S. Sachais, Kathy Chapman, Philip J. Norris, Mars Stone, Paul M. Ness, Steve H. Kleinman

  • June 24, 2026

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