Sex-related peripheral immune profile in ulcerative colitis: links to fatigue - Takeaways - MDSpire

Sex-related peripheral immune profile in ulcerative colitis: links to fatigue

  • By

  • Thyra Albrecht

  • Elisa Wider-Eberspächer

  • Alejandra P. Garza

  • Lorena Morton

  • Sabrina Sulzer

  • Verena Keitel-Anselmino

  • Rosa Rosania

  • Ildiko R. Dunay

  • May 14, 2026

  • 0 min

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  • 1

    Ulcerative colitis is characterized by immune dysregulation, with fatigue being a significant extraintestinal symptom affecting quality of life.

  • 2

    Active ulcerative colitis is associated with increased neutrophils, classical monocytes, and elevated inflammatory cytokines like TNF and BDNF.

  • 3

    Fatigue severity correlates with specific immune cell subsets differently in males and females, highlighting gender-specific immune responses.

  • 4

    Males with ulcerative colitis show a proinflammatory Th17/Th2 profile, while females exhibit ongoing neutrophilia during remission.

  • 5

    Understanding immune profiles in ulcerative colitis can aid in personalized fatigue management and improve patient outcomes.

Original Source(s)

Sex-related peripheral immune profile in ulcerative colitis: links to fatigue

  • by Thyra Albrecht, Elisa Wider-Eberspächer, Alejandra P. Garza, Lorena Morton, Sabrina Sulzer, Verena Keitel-Anselmino, Rosa Rosania, Ildiko R. Dunay

  • May 14, 2026

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