Bidirectional communication between spinal cord injury and gut microbiota, from the bench to the bedside - Takeaways - MDSpire

Bidirectional communication between spinal cord injury and gut microbiota, from the bench to the bedside

  • By

  • Zhaoyang Yin

  • Ge Gong

  • Jian Yin

  • June 19, 2026

  • 0 min

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  • 1

    Spinal cord injury (SCI) disrupts intestinal function and causes gut microbiota imbalance, exacerbating neuroinflammation.

  • 2

    The gut microbiota-gut-spinal cord axis theory highlights the bidirectional relationship between gut microbiota and spinal cord injury.

  • 3

    Alterations in gut microbiota following SCI can serve as biomarkers for injury severity and potential therapeutic targets.

  • 4

    Research indicates that SCI leads to a reduction in butyrate-producing bacteria and an increase in pro-inflammatory cytokines.

  • 5

    Current strategies to modulate gut microbiota for SCI recovery include probiotics, organic acids, and fecal microbiota transplantation.

Original Source(s)

Bidirectional communication between spinal cord injury and gut microbiota, from the bench to the bedside

  • by Zhaoyang Yin, Ge Gong, Jian Yin

  • June 19, 2026

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