An Affordable Ex Vivo Perfusion Model for Myocardial Ischemia-Reperfusion Injury in Wistar Rats: Improving Accessibility in Limited-Resource Environments - Takeaways - MDSpire

An Affordable Ex Vivo Perfusion Model for Myocardial Ischemia-Reperfusion Injury in Wistar Rats: Improving Accessibility in Limited-Resource Environments

  • By

  • Sainath P

  • Shakta Mani Satyam

  • Abdul Rehman

  • Sanjay Bharati

  • Prakashchandra Shetty

  • Mohamed El-Tanani

  • Akheruz Zaman Ahmed

  • Rashmi Kumari

  • Muaweya Sufian Albadawi

  • Firas Assaf

  • Seyed Mohammad Seyed Morteza Hashemi

  • Faisal Aslam Khan

  • Mohmed Krem Adnan Doukarli

  • Marwan Mohamed Hassan Rustom Robari

  • Murk Jai Pal Paryani

  • Varun Kumar Singh

  • Ganesh Kamath S

  • April 29, 2026

  • 0 min

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  • 1

    The study developed a simplified ex vivo rat heart perfusion model to investigate myocardial ischemia-reperfusion injury (IRI) in a cost-effective manner.

  • 2

    Twelve adult male Wistar rats were used, with six assigned to an IRI group and six to a non-ischemic control group for comparative analysis.

  • 3

    The IRI group exhibited a 4.7-fold reduction in coronary flow during early reperfusion, indicating significant vascular dysfunction.

  • 4

    Histopathological analysis confirmed cardiomyocyte degeneration and significant infarct development in the IRI group compared to controls.

  • 5

    This model serves as a proof-of-concept for studying myocardial IRI, addressing accessibility issues in resource-limited research environments.

Original Source(s)

An Affordable Ex Vivo Perfusion Model for Myocardial Ischemia-Reperfusion Injury in Wistar Rats: Improving Accessibility in Limited-Resource Environments

  • by Sainath P, Shakta Mani Satyam, Abdul Rehman, Sanjay Bharati, Prakashchandra Shetty, Mohamed El-Tanani, Akheruz Zaman Ahmed, Rashmi Kumari, Muaweya Sufian Albadawi, Firas Assaf, Seyed Mohammad Seyed Morteza Hashemi, Faisal Aslam Khan, Mohmed Krem Adnan Doukarli, Marwan Mohamed Hassan Rustom Robari, Murk Jai Pal Paryani, Varun Kumar Singh, Ganesh Kamath S

  • April 29, 2026

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