A case of synchronous double primary combined hepatocellular-cholangiocarcinoma complicated with gallbladder adenocarcinoma: a rare case report - Takeaways - MDSpire

A case of synchronous double primary combined hepatocellular-cholangiocarcinoma complicated with gallbladder adenocarcinoma: a rare case report

  • By

  • Xiangfei Wang

  • Linru Yang

  • Haiming Jian

  • Xiaoru Gao

  • Tianxiang Liu

  • May 4, 2026

  • 0 min

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  • 1

    This case report presents a 73-year-old female with synchronous double primary hepatocellular-cholangiocarcinoma and gallbladder adenocarcinoma.

  • 2

    Imaging revealed a space-occupying lesion in the liver and a nodular lesion in the gallbladder, both considered neoplastic.

  • 3

    Postoperative pathology confirmed the liver lesion as combined hepatocellular-cholangiocarcinoma and the gallbladder lesion as adenocarcinoma.

  • 4

    The patient underwent successful surgery, including left hemihepatectomy and cholecystectomy, with no cancerous tissue at resection margins.

  • 5

    This case is the first reported instance of synchronous double primary tumors involving cHCC-CCA and gallbladder adenocarcinoma.

Original Source(s)

A case of synchronous double primary combined hepatocellular-cholangiocarcinoma complicated with gallbladder adenocarcinoma: a rare case report

  • by Xiangfei Wang, Linru Yang, Haiming Jian, Xiaoru Gao, Tianxiang Liu

  • May 4, 2026

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