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1
GLI3 is a context-dependent transcription factor in the Hedgehog signaling pathway with both oncogenic and tumor-suppressive roles.
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2
The balance between GLI3A and GLI3R isoforms influences tumor behavior and is regulated by various signaling networks and microenvironmental factors.
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3
Dysregulated GLI3 signaling is linked to processes such as epithelial–mesenchymal transition, cancer stem cell maintenance, and therapeutic resistance.
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4
GLI3 expression and isoform patterns have potential as diagnostic, prognostic, and susceptibility biomarkers in cancer.
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5
Emerging therapeutic strategies targeting GLI3 include indirect modulation, direct inhibition, and combination approaches.
