Obesity and fertility - Takeaways - MDSpire

Obesity and fertility

  • By

  • Matilde Contessa

  • Maria Rosaria Ambrosio

  • Bruno Fabris

  • Stella Bernardi

  • January 30, 2026

  • 0 min

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  • 1

    Obesity negatively impacts reproductive health by causing conditions like male obesity-related secondary hypogonadism and polycystic ovary syndrome in females.

  • 2

    Metabolism and reproduction are interconnected, with both energy deficiency and excess affecting fertility and pubertal onset.

  • 3

    Leptin plays a crucial role in reproductive function by signaling energy sufficiency and influencing the hypothalamic-pituitary-gonadal axis.

  • 4

    Kisspeptin is essential for reproduction, acting as a mediator between leptin and GnRH neurons to regulate fertility.

  • 5

    GLP-1 receptor agonists show promise in improving reproductive health, potentially offering benefits beyond weight loss.

Original Source(s)

Obesity and fertility

  • by Matilde Contessa, Maria Rosaria Ambrosio, Bruno Fabris, Stella Bernardi

  • January 30, 2026

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