Irisin Mitigates Microglial Inflammation Induced by β-Amyloid through the miR-451a/TLR4/NLRP3 Pathway - Takeaways - MDSpire

Irisin Mitigates Microglial Inflammation Induced by β-Amyloid through the miR-451a/TLR4/NLRP3 Pathway

  • By

  • Roberta Mancuso

  • Marina Saresella

  • Riccardo Nuzzi

  • Simone Agostini

  • Ivana Marventano

  • Ambra Hernis

  • Francesca La Rosa

  • Federica Piancone

  • Mario Clerici

  • April 23, 2026

  • 0 min

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  • 1

    Irisin reduces microglial activation induced by β-amyloid through modulation of the miR-451a/TLR4/NLRP3 pathway.

  • 2

    The study utilized human immortalized microglial cells primed with LPS and stimulated with Aβ1-42 to investigate irisin's effects.

  • 3

    Irisin treatment led to decreased TLR4 expression and NLRP3 inflammasome activation markers, indicating its anti-inflammatory role.

  • 4

    Upregulation of miR-451a and miR-7-5p, along with downregulation of miR-223-3p, was observed following irisin treatment.

  • 5

    The findings suggest that irisin may interact with microRNA pathways to mitigate neuroinflammation relevant to Alzheimer's disease.

Original Source(s)

Irisin Mitigates Microglial Inflammation Induced by β-Amyloid through the miR-451a/TLR4/NLRP3 Pathway

  • by Roberta Mancuso, Marina Saresella, Riccardo Nuzzi, Simone Agostini, Ivana Marventano, Ambra Hernis, Francesca La Rosa, Federica Piancone, Mario Clerici

  • April 23, 2026

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