Isolated anemia in patients with large granular lymphocytic leukemia (LGLL) - Takeaways - MDSpire

Isolated anemia in patients with large granular lymphocytic leukemia (LGLL)

  • By

  • Youssef Salama

  • Fang Zhao

  • Jennifer L. Oliveira

  • Ji Yuan

  • Dragan Jevremovic

  • Ronald S. Go

  • Wei Ding

  • Sameer A. Parikh

  • Mithun V. Shah

  • Paul J. Hampel

  • Aref Al-Kali

  • William G. Morice

  • Min Shi

  • February 22, 2022

  • 0 min

Share

  • 1

    Large granular lymphocytic leukemia (LGLL) is characterized by the clonal expansion of large granular lymphocytes in the blood, bone marrow, and spleen.

  • 2

    Isolated anemia in LGLL is defined as unexplained low hemoglobin levels without accompanying neutropenia or thrombocytopenia.

  • 3

    Diagnosis of LGLL requires detection of clonal LGLL cells and can be challenging without typical clinical presentations.

  • 4

    The study evaluated clinicopathologic features of LGLL presenting with isolated anemia and compared outcomes with patients having pure red cell aplasia.

  • 5

    Treatment responses in LGLL patients were assessed after 16 weeks, with criteria for complete and partial responses defined in the study.

Original Source(s)

Isolated anemia in patients with large granular lymphocytic leukemia (LGLL)

  • by Youssef Salama, Fang Zhao, Jennifer L. Oliveira, Ji Yuan, Dragan Jevremovic, Ronald S. Go, Wei Ding, Sameer A. Parikh, Mithun V. Shah, Paul J. Hampel, Aref Al-Kali, William G. Morice, Min Shi

  • February 22, 2022

Related Content

Luspatercept for the treatment of anemia in allo-HSCT for patients with hematological diseases

Clinical Reasoning in Practice: Implementing High-Value Care When Data Discrepancies Arise

The Molecular Pathology of Non-Malignant Haematological Disease