Comprehensive Evaluation of Biological Age Post-Radiation Therapy in Early-Stage Non-Small Cell Lung Cancer Patients

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Lung cancer is the leading cause of cancer-related death globally, with non-small cell lung cancer (NSCLC) accounting for 80-85% of cases.
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Stereotactic body radiation therapy (SBRT) is an effective treatment for early-stage NSCLC, especially in older patients with comorbidities.
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Accurate assessments of biological age are crucial for personalized treatment decisions in high-risk NSCLC patients undergoing SBRT.
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The study evaluates a deep learning model, FaceAge, for estimating biological age from facial photographs in early-stage NSCLC patients.
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Primary endpoints of the study include overall survival and early mortality, with follow-up conducted through regular medical assessments.

Jama Network Open

by Grace Lee, Fridolin Haugg, Dennis Bontempi, John He, Danielle S. Bitterman, Suraj Pai, Christian Guthier, Kelly J. Fitzgerald, David E. Kozono, Benjamin H. Kann, Hugo J. W. L. Aerts, Raymond H. Mak
April 8, 2026

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