A New Building Block for Nanostructures

NMR, crystallography, and native MS reveal a modular protein–foldamer interface for assembling defined molecular architectures

1

Researchers developed a modular protein–foldamer pair for assembling hybrid nanostructures with controlled geometry.
2

The protein–foldamer interface offers a large, well-defined binding surface, improving assembly positioning compared to existing methods.
3

C10, a variant of the Nanofitin scaffold, was identified as a selective protein partner for the helical aromatic foldamer.
4

Binding studies revealed that C10 binds the foldamer with nanomolar affinity, enabling stable architectural designs.
5

The study demonstrates that artificial foldamers can serve as precise connectors for protein architectures, allowing for customizable assembly.

1