Editorial: Metabolite-induced metabolic reprogramming in the immune system - Takeaways - MDSpire

Editorial: Immune System Metabolic Reprogramming Driven by Metabolites

  • By

  • Jacqueline Oliva-Ramírez

  • Heriberto Prado-Garcia

  • Francisco Javier Sánchez-García

  • July 20, 2026

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  • 1

    Metabolic reprogramming in immune cells has gained attention since the discovery of aerobic glycolysis in tumor cells by Otto Warburg in the 1920s.

  • 2

    Trimethylamine N-oxide (TMAO) is linked to chronic inflammatory diseases like inflammatory bowel disease (IBD) and may serve as a therapeutic target.

  • 3

    Macrophage metabolic profiles vary by location, with alveolar macrophages relying on lipid metabolism and intestinal macrophages on fatty acid oxidation.

  • 4

    Platelets play a role in neutrophil metabolic reprogramming, challenging the notion that neutrophils are solely glycolytic.

  • 5

    Free heme released during sepsis exacerbates cell death and contributes to prolonged inflammation and organ damage in survivors.

Original Source(s)

Editorial: Metabolite-induced metabolic reprogramming in the immune system

  • by Jacqueline Oliva-Ramírez, Heriberto Prado-Garcia, Francisco Javier Sánchez-García

  • July 20, 2026

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