Clinical Significance of Serum Brain-Derived Neurotrophic Factor and Serotonin Levels in Children with Tic Disorders - Takeaways - MDSpire

Clinical Significance of Serum Brain-Derived Neurotrophic Factor and Serotonin Levels in Children with Tic Disorders

  • By

  • Zhang, Xiaoxia

  • Chen, Na

  • Zhu, Xindong

  • Wang, Chen

  • May 13, 2026

  • 0 min

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  • 1

    The study investigated serum levels of BDNF and serotonin in children with tic disorders and their association with disease severity.

  • 2

    Serum BDNF levels were significantly lower in tic disorder patients compared to healthy controls and decreased further in moderate-to-severe cases.

  • 3

    Serum serotonin levels did not differ between mild tic disorder and healthy controls but were significantly reduced in moderate-to-severe cases.

  • 4

    ROC analysis indicated that BDNF and serotonin could help distinguish tic disorder severity, with BDNF showing modest discriminative ability.

  • 5

    Logistic regression identified sleep disturbances, family history of tic disorders, and decreased BDNF as independently associated with tic disorders.

Original Source(s)

Clinical Significance of Serum Brain-Derived Neurotrophic Factor and Serotonin Levels in Children with Tic Disorders

  • by Zhang, Xiaoxia , Chen, Na , Zhu, Xindong , Wang, Chen

  • May 13, 2026

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