The double-edged sword effect of estrogen in kidney disease and its precision modulation - Takeaways - MDSpire

The double-edged sword effect of estrogen in kidney disease and its precision modulation

  • By

  • Jinlan Zhang

  • Jiayi Lyu

  • Miao Deng

  • Jinfen Han

  • Qin Wang

  • Jia Song

  • Rubin Zheng

  • Zhixun Bai

  • June 18, 2026

  • 0 min

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  • 1

    Estrogen has a dual role in kidney disease, providing protective effects while potentially promoting disease under certain pathological conditions.

  • 2

    Sexual dimorphism influences renal function, with premenopausal women showing slower CKD progression, indicating estrogen's protective role.

  • 3

    Estrogen regulates various renal functions, including inflammation, fibrosis, and ion channel activity, impacting kidney health and disease.

  • 4

    Declining estrogen levels in perimenopausal women correlate with increased CKD risk, highlighting the hormone's importance in renal protection.

  • 5

    The complex mechanisms of estrogen's effects in kidney disease necessitate further research to develop targeted therapies and precision medicine.

Original Source(s)

The double-edged sword effect of estrogen in kidney disease and its precision modulation

  • by Jinlan Zhang, Jiayi Lyu, Miao Deng, Jinfen Han, Qin Wang, Jia Song, Rubin Zheng, Zhixun Bai

  • June 18, 2026

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