Normal serum uric acid gout: a neglected and challenging condition - Takeaways - MDSpire

Normal serum uric acid gout: a neglected and challenging condition

  • By

  • Xiu Hong Yang

  • Xiao Li Zhan

  • Qing Xia Xuan

  • Hui Min Jin

  • Zhi Bin Ye

  • June 11, 2026

  • 0 min

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  • 1

    Normal serum uric acid levels during acute gout flares can lead to misdiagnosis, as SUA alone is an unreliable diagnostic marker.

  • 2

    Normal-SUA gout often presents with severe inflammation, fever, and elevated white blood cell counts, complicating diagnosis.

  • 3

    Advanced imaging techniques like ultrasound and dual-energy CT enhance the detection of monosodium urate crystals regardless of SUA levels.

  • 4

    The prevalence of normal SUA during acute gout attacks varies widely, reported between 11% and 63.3% across different studies.

  • 5

    Emerging therapies for normal-SUA gout include anti-IL-1β monoclonal antibodies and NLRP3 inhibitors, showing potential in managing attacks.

Original Source(s)

Normal serum uric acid gout: a neglected and challenging condition

  • by Xiu Hong Yang, Xiao Li Zhan, Qing Xia Xuan, Hui Min Jin, Zhi Bin Ye

  • June 11, 2026

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