De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection - Takeaways - MDSpire

De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection

  • By

  • Sergio Sanhueza

  • Camilo Cabrera

  • Romina Quiroga

  • Bárbara Antilef

  • Camila Muñoz

  • Agustín Vera

  • Ricardo Cartes

  • Liliana Lamperti

  • Enrique Guzmán-Gutiérrez

  • Claudio Aguayo

  • Valeska Ormazábal

  • Mauricio Alejandro Hernández

  • Jaime Lastra

  • Benilde Riffo

  • Gustavo Cerda

  • Luciano Ferrada

  • David De Gonzalo-Calvo

  • María C. García-Hidalgo

  • Mario Henríquez

  • María Inés Barría

  • Ricardo A. Verdugo

  • Alicia Colombo

  • Gonzalo Labarca

  • Estefanía Nova-Lamperti

  • May 4, 2026

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  • 1

    COVID-19 can lead to newly developed insulin resistance (IR) in previously normoglycemic individuals four months post-infection.

  • 2

    Neutrophils from patients with post-COVID-19 IR show increased basal NETosis but impaired responses to TLR7/8 agonists.

  • 3

    Plasma from patients with IR significantly enhances NETosis, indicating a potential link between insulin and NET formation.

  • 4

    The study highlights the importance of managing glucose metabolism disorders post-COVID-19 to mitigate pathological NETosis.

  • 5

    De novo IR after COVID-19 disrupts NETosis primarily through an insulin-enhancing effect, impacting thrombo-inflammatory responses.

Original Source(s)

De novo COVID-19-associated insulin resistance drives dysregulated neutrophil extracellular trap formation (NETosis) four months after infection

  • by Sergio Sanhueza, Camilo Cabrera, Romina Quiroga, Bárbara Antilef, Camila Muñoz, Agustín Vera, Ricardo Cartes, Liliana Lamperti, Enrique Guzmán-Gutiérrez, Claudio Aguayo, Valeska Ormazábal, Mauricio Alejandro Hernández, Jaime Lastra, Benilde Riffo, Gustavo Cerda, Luciano Ferrada, David De Gonzalo-Calvo, María C. García-Hidalgo, Mario Henríquez, María Inés Barría, Ricardo A. Verdugo, Alicia Colombo, Gonzalo Labarca, Estefanía Nova-Lamperti

  • May 4, 2026

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