Outcomes and Risk Factors for Influenza and Respiratory Syncytial Virus Lower Respiratory Tract Infections and Mortality in Patients With Lymphoma or Multiple Myeloma: A 7-Year Retrospective Cohort Study

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The study analyzed 440 patients with lymphoma or multiple myeloma who had RSV or IFV infections from 2016 to 2022.
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Lower respiratory tract infections were diagnosed in 38% of patients, with 57% requiring hospitalization during follow-up.
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Risk factors for lower respiratory tract infections included RSV infection, smoking, steroid exposure, lymphopenia, and high serum creatinine.
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Thirty-day mortality was associated with multiple myeloma diagnosis, smoking, lymphopenia, and nosocomial infections.
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The findings highlight the high burden of respiratory viral infections in lymphoma and multiple myeloma patients and identify key risk factors.

Open Forum Infectious Diseases

by Tali Shafat, Daniel De-la-Rosa-Martinez, Fareed Khawaja, Ying Jiang, Amy Spallone, Marjorie Vieira Batista, Ella Ariza-Heredia, Diana Vilar-Compte, Sairah Ahmed, Melody Becnel, Roy F Chemaly
March 4, 2025

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