IHS, ACP Differ on Migraine Tx

Experts highlight differences between IHS and ACP recommendations as newer therapies reshape acute and preventive migraine care

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The IHS recommends oral triptans as first-line therapy for acute migraine treatment, while the ACP suggests combining triptans with NSAIDs or acetaminophen.
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Gepants are effective for patients who cannot tolerate triptans or are at risk for medication overuse headache, as they do not cause this complication.
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Preventive therapy choice for migraines should consider patient-specific factors, as comparative evidence among treatments is limited and often of low quality.
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CGRP-targeting therapies offer faster response times for migraine prevention but come with significantly higher costs compared to traditional oral medications.
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Management strategies should be patient-centered, addressing modifiable risk factors and informed by individual clinical variables and treatment history.

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