Much of the excess mortality in immunocompromised patients with viral severe acute respiratory infection occurs after ICU discharge - Takeaways - MDSpire
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A substantial share of excess deaths among immunocompromised patients with viral severe acute respiratory infection occurs after ICU discharge

  • By

  • Leyi Xu

  • Ting Ye

  • October 22, 2026

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  • 1

    Among ICU survivors, 10.0% of immunocompromised patients died before hospital discharge, compared with 4.0% of immunocompetent patients.

  • 2

    Post-ICU deaths accounted for approximately one-half of the absolute difference in in-hospital mortality between immunocompromised and immunocompetent patients.

  • 3

    The authors note that treatment limitations, late secondary infection, or progression of underlying disease could contribute to excess mortality after ICU discharge.

  • 4

    The SARI case definition and exclusion of patients with unknown immune status may have affected cohort composition, particularly for COVID-19 admissions.

  • 5

    Approximately three-quarters of the 11.0-point shortfall in 30-day discharge reflected excess hospital mortality rather than a greater proportion remaining hospitalized.

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