Outcome of amniotic membrane transplantation in ocular GVHD-related corneal melting: a retrospective case series - Takeaways - MDSpire

Outcome of amniotic membrane transplantation in ocular GVHD-related corneal melting: a retrospective case series

  • By

  • Xin-Yu Zhuang

  • Yao Xu

  • Zheng-Tai Sun

  • Yue Xu

  • Ying-Jie Chen

  • Xiao-Wen Tang

  • Feng Chen

  • Xiao Ma

  • Xiao-Jing Shi

  • Xiao-Feng Zhang

  • April 30, 2026

  • 0 min

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  • 1

    Single amniotic membrane transplantation (AMT) effectively treats corneal melting due to ocular graft-versus-host disease (oGVHD) after hematopoietic stem cell transplantation.

  • 2

    In a study of 31 patients, 21 achieved corneal healing at 6 months post-AMT, while 10 experienced recurrence of corneal melting.

  • 3

    The incidence of lung graft-versus-host disease (GVHD) was significantly higher in the AMT failure group compared to the success group.

  • 4

    No differences were found in primary disease or donor sources between the AMT success and failure groups.

  • 5

    Postoperative immune regulation and follow-up management are recommended to improve outcomes after AMT for corneal melting.

Original Source(s)

Outcome of amniotic membrane transplantation in ocular GVHD-related corneal melting: a retrospective case series

  • by Xin-Yu Zhuang, Yao Xu, Zheng-Tai Sun, Yue Xu, Ying-Jie Chen, Xiao-Wen Tang, Feng Chen, Xiao Ma, Xiao-Jing Shi, Xiao-Feng Zhang

  • April 30, 2026

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