A Bacteroides strain derived from humans reduces depressive-like behaviors in a rat model subjected to social defeat stress - Takeaways - MDSpire

A Bacteroides strain derived from humans reduces depressive-like behaviors in a rat model subjected to social defeat stress

  • By

  • Marisol I. Dothard

  • Mariaelena Caboni

  • Daniel Norment

  • Nolan Sigmund

  • Sarah M. Allard

  • Jack A. Gilbert

  • Ekaterina Gavrish

  • Gabriel Al-Ghalith

  • Andre Der-Avakian

  • Philip Strandwitz

  • March 10, 2026

  • 0 min

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  • 1

    Depression affects up to 9% of U.S. adults annually and is a leading cause of global disability, characterized by persistent sadness and altered mood states.

  • 2

    The gut-brain axis plays a significant role in mood disorders, with the microbiome influencing neurotransmitter production and behavior.

  • 3

    Oral administration of the human-derived Bacteroides strain HB32 reduced depressive-like behaviors in rats subjected to social defeat stress.

  • 4

    The study compared the effects of B. salyersiae HB32 to ketamine, a known treatment for depression, using a rat model of chronic social stress.

  • 5

    Mechanistic assessments involved vagotomy and multi-omics analysis of brain and fecal samples to explore the gut-brain interaction.

Original Source(s)

A Bacteroides strain derived from humans reduces depressive-like behaviors in a rat model subjected to social defeat stress

  • by Marisol I. Dothard, Mariaelena Caboni, Daniel Norment, Nolan Sigmund, Sarah M. Allard, Jack A. Gilbert, Ekaterina Gavrish, Gabriel Al-Ghalith, Andre Der-Avakian, Philip Strandwitz

  • March 10, 2026

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