Measuring signatures of host resistance, disease tolerance, and damage in human sepsis: a prospective cohort study

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The study evaluated biomarkers related to host resistance, disease tolerance, and tissue damage in sepsis patients.
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Low disease tolerance and high damage were associated with the sepsis subtype exhibiting the highest mortality.
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The research highlights the potential for developing disease tolerance-targeted strategies alongside traditional sepsis treatments.
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Sixteen candidate biomarkers were selected for their relevance to host-response pathways in sepsis.
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The study utilized a prospective cohort design to analyze the relationship between biomarkers and clinical outcomes in sepsis.

Intensive Care Medicine (Springer)

by Arnab Chowdhury, Rachel E. Powell, Jason N. Kennedy, Kelly L. Urbanek, Derek C. Angus, Chung-Chou H. Chang, Lu Tang, Sebastian Weis, Michael Bauer, Manu Shankar-Hari, Christopher W. Seymour
April 7, 2026

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