Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes - Takeaways - MDSpire

Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes

  • By

  • Alberto Moscona-Nissan

  • Daniel Marrero-Rodríguez

  • Sergio Andonegui-Elguera

  • Eduardo Salif Luna-Ávila

  • Florencia Martínez-Mendoza

  • Sandra Vela-Patiño

  • Itzel Ramírez-Ramos

  • Silvia Hinojosa-Alvarez

  • Jesus Hernandez-Perez

  • Rocio A. Chavez-Santoscoy

  • Sophia Mercado-Medrez

  • Kapy S. León-Wu

  • Regina De Miguel-Ibáñez

  • Moisés Mercado

  • Keiko Taniguchi-Ponciano

  • Aldo Ferreira-Hermosillo

  • July 1, 2026

  • 0 min

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  • 1

    MODY is underdiagnosed, with up to 77% of patients lacking significant variants in known MODY genes.

  • 2

    Whole Exome Sequencing identified 14 genes that distinguish MODY from Type 2 Diabetes Mellitus and healthy controls.

  • 3

    Variants in genes MAP2K3, SYT15, KCNJ12, PEX5, and TPTE were found predominantly in MODY cases.

  • 4

    MODY presents a complex genetic architecture in the Mexican population, highlighting the need for tailored diagnostic tools.

  • 5

    The study emphasizes the genetic variability of MODY across populations, particularly in Latino groups.

Original Source(s)

Genomic landscape of Mexican patients with maturity onset diabetes of the young: beyond mutations in MODY-known genes

  • by Alberto Moscona-Nissan, Daniel Marrero-Rodríguez, Sergio Andonegui-Elguera, Eduardo Salif Luna-Ávila, Florencia Martínez-Mendoza, Sandra Vela-Patiño, Itzel Ramírez-Ramos, Silvia Hinojosa-Alvarez, Jesus Hernandez-Perez, Rocio A. Chavez-Santoscoy, Sophia Mercado-Medrez, Kapy S. León-Wu, Regina De Miguel-Ibáñez, Moisés Mercado, Keiko Taniguchi-Ponciano, Aldo Ferreira-Hermosillo

  • July 1, 2026

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