Comparison of Low-Dose and Standard-Dose Intravenous Immunoglobulin for Treating Generalized Myasthenia Gravis: A Prospective Cohort Study at a Single Center - Takeaways - MDSpire

Comparison of Low-Dose and Standard-Dose Intravenous Immunoglobulin for Treating Generalized Myasthenia Gravis: A Prospective Cohort Study at a Single Center

  • By

  • Haocheng Luo

  • Li Dong

  • Li Yang

  • Yufei Deng

  • Chaoyue Zhang

  • Xuxiang Zhang

  • Liqing Hu

  • Zhenyu Wu

  • Xiaojun Yang

  • Qilong Jiang

  • April 28, 2026

  • 0 min

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  • 1

    This study compared low-dose IVIG (≤0.2 g/kg/day) to standard-dose IVIG (0.4 g/kg/day) in adults with generalized myasthenia gravis.

  • 2

    Both low-dose and standard-dose IVIG regimens showed significant clinical improvement in MG-ADL and QMG scores over 12 weeks.

  • 3

    No significant differences in clinical outcomes were found between the low-dose and standard-dose IVIG groups at any follow-up visit.

  • 4

    Prednisone requirements did not decrease over 12 weeks for either treatment group, indicating no clear steroid-sparing effect.

  • 5

    The findings suggest that low-dose IVIG may be effective for short-term treatment of gMG, warranting further investigation.

Original Source(s)

Comparison of Low-Dose and Standard-Dose Intravenous Immunoglobulin for Treating Generalized Myasthenia Gravis: A Prospective Cohort Study at a Single Center

  • by Haocheng Luo, Li Dong, Li Yang, Yufei Deng, Chaoyue Zhang, Xuxiang Zhang, Liqing Hu, Zhenyu Wu, Xiaojun Yang, Qilong Jiang

  • April 28, 2026

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