Association between baseline-stratified trajectory subgroups of serum albumin and outcomes in critically ill patients with early sepsis-associated acute kidney injury: a retrospective study - Takeaways - MDSpire

Association between baseline-stratified trajectory subgroups of serum albumin and outcomes in critically ill patients with early sepsis-associated acute kidney injury: a retrospective study

  • By

  • Qiang Gao

  • Xinwu Lai

  • Yu Tian

  • Tingting Wang

  • Xiangde Zheng

  • An Zhang

  • May 29, 2026

  • 0 min

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  • 1

    The study analyzed 1,914 patients with early sepsis-associated acute kidney injury (SA-AKI) from the MIMIC-IV database.

  • 2

    Five baseline-stratified trajectory subgroups of serum albumin levels were identified, impacting mortality risk and hospital length of stay.

  • 3

    Patients with a steady-state albumin trajectory at 2.0 g/dL had significantly higher mortality risks at multiple time points compared to those at 3.0 g/dL.

  • 4

    A trajectory level of >4.1 g/dL was associated with increased 365-day mortality risk among critically ill sepsis patients.

  • 5

    The association between serum albumin trajectories and mortality risk varied based on age and sex, confirmed by sensitivity analysis.

Original Source(s)

Association between baseline-stratified trajectory subgroups of serum albumin and outcomes in critically ill patients with early sepsis-associated acute kidney injury: a retrospective study

  • by Qiang Gao, Xinwu Lai, Yu Tian, Tingting Wang, Xiangde Zheng, An Zhang

  • May 29, 2026

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