Interleukin-10 at the crossroads of immunity in TLR7-induced lupus

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Interleukin-10 (IL-10) has both pro-inflammatory and anti-inflammatory effects in systemic lupus erythematosus (SLE).
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IL-10 modestly limits disease progression in a TLR7 agonist-induced murine model of lupus, indicating its regulatory effects.
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Blockade of IL-10 receptors increased IL-17 and reduced regulatory T cell frequencies in the CD4 T-cell compartment.
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IL-10 signaling primarily activates STAT3 pathways in T effector and regulatory T cells, influencing immune responses.
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The dual role of IL-10 in lupus suggests that its effects may vary based on the disease context and local microenvironment.

Frontiers In Immunology

by Johanna Pauline Williams, Anaïs Amend, Anna-Lena Schäfer, Paola Fernanda Ruiz-Aparicio, Antoine Nicolas Kraemer, Aileen Qian Luo, Laura Riechert, Lara Weber, Baerbel Keller, Rudolf Armin Manz, Reinhard Edmund Voll, Nina Chevalier
June 22, 2026

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