Efficacy and safety of needle-free jet injection of self-crosslinking hyaluronic acid for facial fine wrinkles and skin texture: 12-week clinical outcomes in Asian women - Takeaways - MDSpire

Efficacy and safety of needle-free jet injection of self-crosslinking hyaluronic acid for facial fine wrinkles and skin texture: 12-week clinical outcomes in Asian women

  • By

  • Kyu-Ho Yi

  • Yerin Park

  • Soo-Yeon Lee

  • Han Earl Lee

  • Atchima Suwanchinda

  • July 14, 2026

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  • 1

    The study evaluated the effects of needle-free jet injection of self-crosslinking hyaluronic acid on facial fine wrinkles in Asian women.

  • 2

    Thirty women aged 40–55 years with visible fine wrinkles underwent three treatment sessions at 4-week intervals.

  • 3

    At week 12, significant reductions in wrinkle and texture scores were observed, with improvements in both malar and pericommissural regions.

  • 4

    Sixty percent of participants reported moderate to marked improvement, and treatment-related reactions were mild and transient.

  • 5

    The study suggests that needle-free jet delivery of self-crosslinking HA may improve fine wrinkles and skin texture.

Original Source(s)

Efficacy and safety of needle-free jet injection of self-crosslinking hyaluronic acid for facial fine wrinkles and skin texture: 12-week clinical outcomes in Asian women

  • by Kyu-Ho Yi, Yerin Park, Soo-Yeon Lee, Han Earl Lee, Atchima Suwanchinda

  • July 14, 2026

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