Cytomegalovirus DNAemia in Hospitalized Adults With SARS-CoV-2 Infection Requiring Supplemental Oxygen: Virologic and Clinical Characteristics and Association With Outcomes - Takeaways - MDSpire

Cytomegalovirus DNAemia in Hospitalized Adults With SARS-CoV-2 Infection Requiring Supplemental Oxygen: Virologic and Clinical Characteristics and Association With Outcomes

  • By

  • Michael Boeckh

  • Hu Xie

  • Terry Stevens-Ayers

  • Linda Sircy

  • Danniel Zamora

  • Jason D Goldman

  • Christopher W Woods

  • Renee D Stapleton

  • Gordon Rubenfeld

  • Andre Kalil

  • Keith R Jerome

  • Sayan Dasgupta

  • Ajit P Limaye

  • December 31, 2025

  • 0 min

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  • 1

    Cytomegalovirus (CMV) reactivation is associated with worse clinical outcomes in hospitalized adults with COVID-19 requiring oxygen support.

  • 2

    The cumulative incidence of CMV DNAemia among seropositive patients by day 28 was 11%, with higher rates in those with more severe COVID-19.

  • 3

    Older age, male sex, lymphopenia, and systemic corticosteroid use were identified as risk factors for CMV DNAemia in COVID-19 patients.

  • 4

    CMV DNAemia was linked to a lower probability of clinical improvement and higher SARS-CoV-2 viral load, indicating delayed recovery.

  • 5

    Increased CMV viral load was associated with higher mortality rates among hospitalized adults with COVID-19.

Original Source(s)

Cytomegalovirus DNAemia in Hospitalized Adults With SARS-CoV-2 Infection Requiring Supplemental Oxygen: Virologic and Clinical Characteristics and Association With Outcomes

  • by Michael Boeckh, Hu Xie, Terry Stevens-Ayers, Linda Sircy, Danniel Zamora, Jason D Goldman, Christopher W Woods, Renee D Stapleton, Gordon Rubenfeld, Andre Kalil, Keith R Jerome, Sayan Dasgupta, Ajit P Limaye

  • December 31, 2025

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