Activation of ROS-driven genomic instability, mitochondrial depolarization, and p53-independent apoptotic cell death in human A431 epidermoid skin cancer cells by bioactive glass nanoparticles - Takeaways - MDSpire

Activation of ROS-driven genomic instability, mitochondrial depolarization, and p53-independent apoptotic cell death in human A431 epidermoid skin cancer cells by bioactive glass nanoparticles

  • By

  • Hanan R H Mohamed

  • Shahd Mosaad

  • Aya A. Osman

  • Alaa H. Elsewedy

  • Habiba M. Zaki

  • Mayada E. Borai

  • Gehan Safwat

  • April 2, 2026

  • 0 min

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  • 1

    Epidermoid skin cancer (cSCC) is the second most common non-melanoma skin cancer, accounting for about 20% of cutaneous malignancies.

  • 2

    Bioactive glass nanoparticles (BGNPs) exhibit potential anticancer properties by inducing reactive oxygen species and genomic instability in cancer cells.

  • 3

    This study is the first to evaluate the cytotoxic effects of BGNPs specifically in human A431 epidermoid carcinoma cells.

  • 4

    BGNPs demonstrate selective cytotoxicity against cancer cells while showing minimal toxicity to normal skin cells.

  • 5

    The findings suggest that BGNPs could serve as novel, targeted nanotherapeutics for treating epidermoid skin cancer.

Original Source(s)

Activation of ROS-driven genomic instability, mitochondrial depolarization, and p53-independent apoptotic cell death in human A431 epidermoid skin cancer cells by bioactive glass nanoparticles

  • by Hanan R H Mohamed, Shahd Mosaad, Aya A. Osman, Alaa H. Elsewedy, Habiba M. Zaki, Mayada E. Borai, Gehan Safwat

  • April 2, 2026

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