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1
Metabolic flexibility is essential for health, allowing efficient switching between glucose and lipid substrates based on nutritional and energetic demands.
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2
Impaired metabolic flexibility can lead to insulin resistance, ectopic lipid deposition, and chronic inflammation, contributing to various metabolic disorders.
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3
Composite indices like TyG and VAI enhance metabolic risk assessment by integrating glucose-lipid abnormalities rather than relying on isolated biomarkers.
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4
Dietary quality, macronutrient composition, and meal timing significantly influence metabolic flexibility and responses to dietary interventions.
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5
Regular exercise improves glucose-lipid homeostasis and metabolic flexibility, highlighting the importance of substrate handling and systemic adaptations.
