Tongue cancer microbial biomarkers: landscape of saliva, cancer tissue, and para-carcinoma tissue

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Oral cancer is a global health challenge, with two-thirds of patients diagnosed at advanced stages due to ineffective early screening methods.
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This pilot study analyzed microbial composition in saliva and tissues from 24 tongue cancer patients, revealing significant differences from healthy individuals.
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Specific bacteria, including acinetobacter calcoaceticus and burkholderia cepacia, were prevalent in cancer tissues, suggesting their potential as biomarkers.
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Saliva from tongue cancer patients showed higher abundance of certain bacteria, indicating its potential as a non-invasive screening tool for early detection.
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Findings are preliminary and require validation in larger studies, emphasizing the need for rigorous controls in future research on microbial biomarkers.

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