GLP-1 and GIP Changes after Sleeve Gastrectomy and Weight Regain in Adolescents. Do we need a Boost? - Takeaways - MDSpire

GLP-1 and GIP Changes after Sleeve Gastrectomy and Weight Regain in Adolescents. Do we need a Boost?

  • By

  • Mohamed Shehata

  • Ahmed Elhaddad

  • Mohamed Mansour

  • Sherif Shehata

  • Ashraf El Attar

  • September 1, 2025

  • 0 min

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  • 1

    Adolescent obesity is increasingly prevalent and poses long-term health risks, leading to interest in bariatric surgery, particularly laparoscopic sleeve gastrectomy (LSG).

  • 2

    LSG significantly alters gut hormones, particularly GLP-1 and GIP, which initially contribute to weight loss and improved insulin sensitivity but may decline over time.

  • 3

    Weight regain (WR) typically occurs 2–3 years post-LSG, associated with declining incretin responses and potential anatomical or behavioral adaptations.

  • 4

    Long-term studies confirm LSG's effectiveness in adolescents, showing sustained weight loss and improvements in metabolic health over a seven-year follow-up.

  • 5

    Pharmacological agents like semaglutide may serve as adjunctive strategies to mitigate WR in adolescents who have undergone LSG.

Original Source(s)

GLP-1 and GIP Changes after Sleeve Gastrectomy and Weight Regain in Adolescents. Do we need a Boost?

  • by Mohamed Shehata, Ahmed Elhaddad, Mohamed Mansour, Sherif Shehata, Ashraf El Attar

  • September 1, 2025

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