Vascular Alterations in the Choroid of Eyes Affected by Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy: Fresh Perspectives - Takeaways - MDSpire

Vascular Alterations in the Choroid of Eyes Affected by Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy: Fresh Perspectives

  • By

  • Nicola Valsecchi

  • Matteo Elifani

  • Chiara Veronese

  • Emilia Maggio

  • Antonio Moramarco

  • Mohammed Abdul Rasheed

  • Grazia Pertile

  • Kiran Kumar Vupparaboina

  • Jay Chhablani

  • Luigi Fontana

  • Maurizio Mete

  • February 11, 2026

  • 0 min

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  • 1

    Acute macular neuroretinopathy (AMN) is a rare condition characterized by acute photopsia, paracentral scotoma, and reduced visual acuity.

  • 2

    Paracentral acute middle maculopathy (PAMM) is distinguished from AMN by hyperreflectivity of the inner nuclear layer on OCT imaging.

  • 3

    Recent studies suggest that choroidal hypoperfusion may be the primary mechanism underlying AMN, challenging previous beliefs about deep capillary plexus involvement.

  • 4

    The study aimed to quantify choroidal thickness and vascularity index in AMN and compare findings with PAMM to refine the distinction between these conditions.

  • 5

    A retrospective, multicentric study included patients diagnosed with AMN and PAMM, adhering to ethical guidelines and obtaining informed consent.

Original Source(s)

Vascular Alterations in the Choroid of Eyes Affected by Acute Macular Neuroretinopathy and Paracentral Acute Middle Maculopathy: Fresh Perspectives

  • by Nicola Valsecchi, Matteo Elifani, Chiara Veronese, Emilia Maggio, Antonio Moramarco, Mohammed Abdul Rasheed, Grazia Pertile, Kiran Kumar Vupparaboina, Jay Chhablani, Luigi Fontana, Maurizio Mete

  • February 11, 2026

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