Biogenic Caralluma sinaica-derived silver nanoparticles as a synergistic antibacterial and osteoinductive nanoplatform for osteomyelitis management - Takeaways - MDSpire

Biogenic Caralluma sinaica-derived silver nanoparticles as a synergistic antibacterial and osteoinductive nanoplatform for osteomyelitis management

  • By

  • Aldayel, Munirah F

  • Ali, Enas M

  • Abdallah, Basem M

  • May 11, 2026

  • 0 min

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  • 1

    Osteomyelitis is an inflammatory bone disease caused by infectious microorganisms, presenting treatment challenges due to antibiotic resistance.

  • 2

    Green phytosynthesized silver nanoparticles (CS-AgNPs) were developed using Caralluma sinaica methanolic leaf extract.

  • 3

    CS-AgNPs/PE demonstrated significant antibacterial potency against Staphylococcus aureus, reducing MIC and MBC values.

  • 4

    Treatment with CS-AgNPs/PE resulted in reduced bacterial burden and inflammatory response in an osteomyelitis mouse model.

  • 5

    CS-AgNPs/PE increased osteocalcin positive osteoblasts and collagen deposition, indicating osteoinductive effects.

Original Source(s)

Biogenic Caralluma sinaica-derived silver nanoparticles as a synergistic antibacterial and osteoinductive nanoplatform for osteomyelitis management

  • by Aldayel, Munirah F, Ali, Enas M, Abdallah, Basem M

  • May 11, 2026

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