A Randomized Controlled Trial Assessing the Impact of a Repair Balm with Prebiotic and Panthenol on the Tolerability of Topical 5-Fluorouracil Therapy for Actinic Keratoses - Takeaways - MDSpire

A Randomized Controlled Trial Assessing the Impact of a Repair Balm with Prebiotic and Panthenol on the Tolerability of Topical 5-Fluorouracil Therapy for Actinic Keratoses

  • By

  • Anne Tseng

  • Regina Yu

  • Susan Brown

  • Nicholas Muller

  • Samuel X. Tan

  • Edwige Roy

  • Suzanne Nguyen

  • Delphine Kerob

  • Kiarash Khosrotehrani

  • April 29, 2026

  • 0 min

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  • 1

    Topical 5-fluorouracil is effective for treating actinic keratoses but often leads to local skin reactions that hinder treatment completion.

  • 2

    The study evaluated the impact of a prebiotic and panthenol-containing repair balm (BB5+) on the tolerability of 5-fluorouracil therapy.

  • 3

    Adjunctive use of BB5+ did not significantly improve treatment completion but reduced local skin reaction severity and enhanced quality of life.

  • 4

    Barrier repair strategies like BB5+ may improve patient experience during field therapy for actinic keratoses without compromising treatment efficacy.

  • 5

    The trial was conducted in Queensland, Australia, with adults aged 18 and older receiving topical 5-fluorouracil for actinic keratoses.

Original Source(s)

A Randomized Controlled Trial Assessing the Impact of a Repair Balm with Prebiotic and Panthenol on the Tolerability of Topical 5-Fluorouracil Therapy for Actinic Keratoses

  • by Anne Tseng, Regina Yu, Susan Brown, Nicholas Muller, Samuel X. Tan, Edwige Roy, Suzanne Nguyen, Delphine Kerob, Kiarash Khosrotehrani

  • April 29, 2026

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