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Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide, with significant incidence rates in both developed and developing countries.
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GLOBOCAN 2022 data reveals a notable rise in CRC incidence among individuals under 50, indicating a shifting age-related disease burden.
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Non-modifiable risk factors for CRC include hereditary syndromes and chronic inflammatory conditions, while lifestyle factors like diet and sedentary behavior are modifiable.
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The study employs a four-dimensional analytical framework to assess geographic, demographic, and socioeconomic disparities in CRC incidence and mortality.
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Findings aim to inform CRC prevention strategies, optimize screening guidelines, and contribute to global efforts to reduce preventable cancer deaths by 2030.
