Association between hypertension and risk of respiratory failure and mortality in patients with COVID-19: a retrospective cohort study with predictive model development - Takeaways - MDSpire

Association between hypertension and risk of respiratory failure and mortality in patients with COVID-19: a retrospective cohort study with predictive model development

  • By

  • Xiaoqing Hu

  • Kailong Ye

  • Bifang Miao

  • Yiqun Dai

  • Lianghua Guo

  • Linmiao Zeng

  • Xiu Chen

  • Chuanqi Zhu

  • Qinghua Zhang

  • Bin Song

  • Jianhong Xiao

  • May 7, 2026

  • 0 min

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  • 1

    Hypertension is independently associated with increased risks of respiratory failure and in-hospital mortality in COVID-19 patients.

  • 2

    Eosinophil count and estimated glomerular filtration rate (eGFR) partially mediate the relationship between hypertension and adverse COVID-19 outcomes.

  • 3

    The study utilized propensity score matching to enhance comparability between hypertensive and non-hypertensive COVID-19 patients.

  • 4

    A LASSO-based risk prediction model demonstrated good predictive performance for respiratory failure and mortality in hypertensive patients.

  • 5

    The findings support early risk identification and precision clinical decision-making for hypertensive individuals with COVID-19.

Original Source(s)

Association between hypertension and risk of respiratory failure and mortality in patients with COVID-19: a retrospective cohort study with predictive model development

  • by Xiaoqing Hu, Kailong Ye, Bifang Miao, Yiqun Dai, Lianghua Guo, Linmiao Zeng, Xiu Chen, Chuanqi Zhu, Qinghua Zhang, Bin Song, Jianhong Xiao

  • May 7, 2026

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